Table 1.
Demographic characteristics and co-morbidities of patients with postoperative bleeding after cardiac surgery employing cardiopulmonary bypass
| Variables | I Group n=38 | II Group n=41 | P value |
|---|---|---|---|
|
Demographic |
|
|
|
| Sex (male/female) |
21/17 |
17/24 |
0.5 |
| Age (years) |
67 ± 10 |
66 ± 10 |
0.7 |
| EuroSCORE (%) |
4.8 ± 2 |
4.9 ± 1.7 |
0.2 |
| BMI (kg/m2) |
27.6 ± 4.8 |
28.3 ± 4.6 |
0.5 |
| EF (%) |
55 ± 8.8 |
56 ± 6.7 |
0.2 |
| Hypertension (n) |
13 |
22 |
0.1 |
| Previous myocardial infarction (n) |
13 |
13 |
1.0 |
| Hypercholesterolemia (n) |
6 |
11 |
0.2 |
| Pulmonary obstructive disease (n) |
5 |
3 |
0.48 |
|
Preoperative medication |
|
|
|
| Aspirin (n) |
26 |
29 |
0.7 |
| Clopidogrel (n) |
6 |
9 |
0.44 |
| LMWH (n) |
31 |
25 |
0.42 |
| Warfarin (n) |
2 |
1 |
0.6 |
|
Preoperative coagulation tests |
|
|
|
| PT (%) |
87 ± 15 |
92 ± 12 |
0.15 |
| APTT (sec.) |
34 ± 6 |
32 ± 4 |
0.05 |
| Fibrinogen (g/L) |
4.4 ± 1.1 |
4.7 ± 1.5 |
0.25 |
| PLT (x109/L) |
205 ± 39 |
225 ± 72 |
0.24 |
|
Surgical parameters |
|
|
|
| CABG (n) |
16 |
17 |
0.9 |
| Valve replacement (n) |
13 |
16 |
0.6 |
| Combined surgery (n) |
8 |
9 |
0.8 |
| CPB duration (min) |
106 ± 40 |
102 ± 41 |
0.8 |
| Aorta occlusion time (min) |
66 ± 25 |
64 ± 29 |
0.4 |
| Reperfusion time (min) |
35 ± 15 |
32 ± 15 |
0.5 |
| Blood loss 24h (ml) |
812 ± 269 |
346 ± 102 |
<0.001 |
| Erythrocyte requirements during ICU stay (n) |
14 |
3 |
0.008 |
| Plasma requirements during ICU stay (n) |
14 |
1 |
0.001 |
| Cryoprecipitate requirements during ICU stay (n) | 7 | 1 | 0.03 |
Data are presented as mean ± SD or number (n).
BMI, body mass index; EF, ejection fraction; LMWH, low molecular weight heparin; PT, prothrombin time; APTT, activated partial thromboplastin time; PLT, platelet count; CABG, coronary artery bypass grafting; CPB, cardiopulmonary bypass; ICU, intensive care unite; n, number of patients.