Table 4.
The top 10 instances obtained from gene modularization comparison method and distance comparison method in Alzheimer case
| A. | cMap ID | Molecule | GO counts | B. | cMap ID | Molecule |
|---|---|---|---|---|---|---|
| 415 | nordihydroguaiaretic acid | 25- | 367 | fulvestrant | ||
| 966 | tretinoin [INN] | 22- | 447 | tretinoin | ||
| 513 | LY-294002 | 21- | 3 | metformin | ||
| 367 | fulvestrant [INN] | 20+ | 582 | butein | ||
| 1048 | alpha-estradiol | 18- | 419 | chlorpromazine | ||
| 988 | estradiol [INN] | 15- 1+ | 942 | prazosin | ||
| 953 | monorden | 16- 1+ | 970 | 5230742 | ||
| 502 | prazosin [INN] | 17+ | 448 | trichostatin A | ||
| 361 | LY-294002 | 9- 8+ | 254 | SC-58125 | ||
| 866 | ikarugamycin | 16+ | 460 | deferoxamine |
The top 10 instances sharing the largest number of significantly affected GOMs with Alzheimer hippocampus cells are listed in A and the top 10 instances resulted from distance comparison method are listed in B.
For detailed parameter settings: GO mode: BP; P-value: < 0.05.