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. 2012 Dec 17;7(12):e51800. doi: 10.1371/journal.pone.0051800

Table 5. Susceptibilities of C. jejuni 11168 and its efflux mutants to the selected plant extracts in the presence or absence of PAβN (20 µg/mL)a, NMP (100 µg/mL) a, verapamil (100 µg/mL), reserpine (100 µg/mL) or CCCP (0.25µg/mL)b.

Extract ±inhibitor 11168 11168B 11168F 11168R
MIC (µg/mL) Fold diff. MIC (µg/mL) Fold diff. MIC (µg/mL) Fold diff. MIC (µg/mL) Fold diff.
I18 313 19.5 625 156
+PAβN <0.6 >512 19.5 1 39 16 39 4
+NMP 19.5 16 39 0.5 313 2 19.5 8
+Verapamil 39 8 19.5 1 625 1 156 1
+Reserpine 19.5 16 4.9 4 625 1 156 1
+CCCP 4.9 64 9.8 2 313 2 156 1
V40 78 9.8 156 156
+PAβN 4.9 16 <0.3 ≥32 9.8 16 9.8 16
+NMP 19.5 4 <4.9 ≥2 78 2 78 2
+Verapamil 39 2 04.9 2 156 1 156 1
+Reserpine 39 2 9.8 1 78 2 78 2
+CCCP 4.9 16 9.8 1 78 2 156 1
V70 78 4.5 78 78
+PAβN 19.5 4 9.8 0.5 <1.2 ≥64 78 1
+NMP 39 2 9.8 0.5 19.5 2 39 2
+Verapamil 78 1 9.8 0.5 78 1 156 0.5
+Reserpine 78 1 9.8 0.5 78 1 156 0.5
+CCCP 39 2 4.5 1 39 2 78 1
A40 156 2.4 156 313
+PAβN 39 4 0.3 8 78 2 39 8
+NMP 78 2 0.3 8 39 4 39 8
+Verapamil 156 1 1.2 2 313 0.5 313 1
+Reserpine 156 1 2.4 1 313 0.5 313 1
+CCCP 39 4 2.4 1 156 1 313 1
Babić 8,000 4,000 8,000 8,000
+PAβN 2,000 4 250 16 500 8 500 8
+NMP 1,000 8 1,000 4 2,000 2 2,000 2
+Verapamil 8,000 1 2,000 2 4,000 1 2,000 2
+Reserpine 8,000 1 4,000 1 4,000 1 2,000 2
+CCCP 125 64 125 32 125 32 125 32

Fold diff.” indicates fold difference, which is calculated using the formula: MIC without an EPI/MIC with an EPI. ≥4-fold changes are indicated in bold.

a

PAβN and NMP significantly (p<0.05) reduced the MICs of the plant extracts in 11168, 11168F and 11168R, but not in 11168B (p > 0.05).

b

The effect of CCCP on the MICs of the plant extracts was only significant with 11168 (p<0.05).