Figure 3. Hepatic expression of gluco-regulatory enzymes after acutely normalizing blood glucose in glucose transporter 4 over-expressing mice (G4Tg) and wild-type (WT) littermates.

Hepatic expression of glucokinase (GK; A), glucose-6-phosphatase (G6Pase; B), and cytosolic phosphoenolpyruvate kinase (PEPCK; C) are shown before and after normalizing blood glucose in 5h-fasted mice that over-express glucose transporter 4 (Glut4) in skeletal muscle, heart, and adipose tissue (G4Tg) and wild-type (WT) littermates during a 90 min phloridzin (80 μg·kg⁻¹·min⁻¹)-glucose (115 mg·dL⁻¹) clamp. Separate cohorts of mice were used to obtain basal and clamp data. Data are presented as means ± SEM and normalized to cyclophilin expression and basal levels in WT mice. * and ϕ indicate p<0.05 compared to WT littermates or to basal values within a genotype, respectively. n = 7–8 mice in each group.