Figure 1. Body weight, body composition, voluntary activity, and gene expression of BER glycosylases.
Body weights were measured weekly during the feeding period, and change in body weight from initial body weight was calculated (A). Body composition was measured by NMR at 0 and 4 weeks after the start of feeding, and change in fat mass was calculated (B). Voluntary physical activity was measured by recording wheel running in individually caged, chow-fed mice for 2 weeks (C). Expression of key glycosylases initiating BER of oxidized DNA was measured by qRT-PCR (D). n = 6 for each group; *, p<0.05 vs. WT, #, p<0.05 vs. chow-fed mice.