Table 2. Regulation of inflammatory response and cell movement-associated genes in the core and perriinfarct after permanent focal cerebral ischemia.
| Symbol | Gene Name | 24 h | 3 d | ||
| Core | Periinfarct | Core | Periinfarct | ||
| Inflammatory Reponse | |||||
| TLR2 | Toll-Like Receptor 2 | 2.59 (<10−4) | 2.36 (<0.01) | 8.34 (<10−10) | 4.00 (<10−4) |
| IL1RL1 | Interleukin 1 receptor-like 1 | 13.8 (<10−4) | 15.5 (<10−5) | 57.7 (<10−8) | 12.2 (<10−4) |
| IL1B | Interleukin-1 beta | 21.9 (<10−7) | 13.3 (<10−6) | 13.5 (<10−6) | 3.89 (<0.05) |
| IL4RA | Interleukin-4 receptor, alpha | 4.17 (<10−5) | 4.06 (<10−5) | 5.24 (<10−7) | 2.53 (<0.01) |
| IL6RA | Interleukin-6 receptor, alpha | 2.87 (<10−6) | 3,43 (<10−8) | 3.92 (<10−9) | 2,53 (<10−5) |
| IL7R | Interleukin-7 receptor | 2.42 (<0.05) | 2.13 (<0.05) | 5.24 (<10−5) | 3.23 (<0.01) |
| IL13RA1 | Interleukin 13 receptor, alpha 1 | 2.81 (<0.01) | 2.69 (<0.01) | 5.28 (<10−6) | 2.48 (<0.05) |
| IL17RE | interleukin 17 receptor E | – | 4.63 (<10−6) | – | – |
| IL18 | Interleukin-18 | 2.11 (<0.05) | 2.73 (<10−5) | 8.05 (<10−11) | 3.53 (<10−6) |
| IL33 | Interleukin-33 | – | 0.50 (<10−5) | – | – |
| Cellular Movement | |||||
| SEMA3A | Semaphorin-3A | – | – | 0.34 (<10−5) | – |
| SEMA4F | Semaphorin-4F | – | 0.46 (<10−5) | – | – |
| NOS3 | Nitric oxide synthase 3 | 2.62 (<10−4) | 2.49 (<10−4) | – | – |
| GUCY1A3 | Guanylate cyclase soluble subunit alpha 3 | 0.29 (<10−6) | 0.42 (<10−4) | 0.40 (<10−4) | – |
| ADM | Adrenomedullin | 4.29 (<10−5) | 3.92 (<10−5) | 3.97 (<10−6) | 2.06 (<0.05) |
| HAS1 | Hyaluronan synthase 1 | 144.01 (<10−9) | 145.2 (<10−9) | 14.52 (<10−5) | 4.92 (<0.05) |
| CXCR4 | C-X-C chemokine receptor type 4 | – | – | 9.51 (<10−8) | 3.25 (<0.01) |
| COL4A1 | Collagen, type IV, alpha 1 | 3.73 (<10−4) | 4.11 (<10−5) | 5.43 (<10−6) | 2.62 (<0.01) |
| FN1 | Fibronectin | 2.36 (<10−4) | 3.27 (<10−5) | 8,18 (<10−9) | 3.36 (<10−4) |
| ICAM1 | Intercellular Adhesion Molecule 1 | 5.73 (<10−7) | 5.54 (<10−7) | 5.31 (<10−7) | 2.64 (<0.01) |
| PAK1 | Serine/threonine-protein kinase PAK 1 | – | 0.45 (<10−5) | 0.44 (<10−5) | – |
| S100A9 | S100A9 | 20.4 (<10−5) | 15.1 (<10−4) | 29.7 (<10−6) | 8.81 (<0.01) |
| SLIT2 | calgranulin-B | – | 0.49 (<10−5) | – | – |
| STAT3 | Signal transducer and activator of transcription 3 | 3.97 (<10−8) | 3.29 (<10−6) | 2.66 (<10−4) | – |
| NRCAM | Neuronal cell adhesion molecule | – | 0.44 (<10−5) | 0.41 (<10−6) | – |
Expression is given by fold change in value compared with healthy controls. Adjusted p-value (AdjP) is given in parenthesis.