Table 3. Regulation of gene expression and tissue development-associated genes in the core and periinfarct after permanent focal cerebral ischemia.

Symbol	Gene Name	24 h		3 d
		Core	Periinfarct	Core	Periinfarct
Gene Expression
REST	RE1-silencing transcription factor	2.33 (<0.01)	2.97 (<0.01)	3,81 (<10−6)	2.16 (<0.05)
SMAD1	SMAD family member 1	2.35 (<10−9)	2.69 (<10−11)	–	–
STAT4	Signal transducer and activator of transcription 4	0,49 (<0.01)	–	0.35 (<10−6)	–
FAS	TNF receptor superfamily, member 6	3.73 (<10−5)	4.08 (<10−5)	7.16 (<10−8)	4.32 (<10−5)
MYC	Myc proto-oncogene protein	7.62 (<10−9)	6.87 (<10−8)	6.15 (<10−9)	3.01 (<10−4)
HIF1A	Hypoxia-inducible factor 1, alpha	2.11 (<10−8)	–	–	–
ARNT2	Aryl hydrocarbon receptor nuclear translocator 2	–	–	–	–
Tissue Development
NOTCH3	Neurogenic locus notch homolog protein 3	–	2.14 (<0.05)	2,45 (<0.05)	–
NOCTH4	Neurogenic locus notch homolog protein 4	–	2.03 (<10−4)	–	–
NOG	Noggin	–	–	0,42 (<10−6)	–
SOX7	Sox-7 transcription factor	6.77 (<10−7)	5.03 (<10−6)	3.97 (<10−6)	2.20 (<0.05)
HES1	Transcription factor HES-1	–	–	–	–
HES2	Transcription factor HES-2	–	3.14 (<0.05)	–	–
HES5	Transcription factor HES-5	0.18 (<10−6)	0.16 (<10−6)	0.41 (<0.01)	–
NEUROD1	Neurogenic differentiation 1	0.40 (<10−5)	–	0.36 (<10−6)	–
MMP2	Matrix metalloproteinase-2	–	–	5.82 (<10−10)	3.81 (<10−6)
MMP7	Matrix metalloproteinase-7	–	–	81,0 (<10−7)	13,0 (<0.01)
MMP9	Matrix metalloproteinase-9	5.94 (<10−6)	4.03 (<10−5)	3.01 (<10−4)	2.31 (<0.05)
MMP12	Matrix metalloproteinase-12	24,8 (<10−5)	27,7 (<10−5)	125 (<10−8)	22,3 (<10−4)

Expression is given by fold change in value compared with healthy controls. Adjusted p-value (AdjP) is given in parenthesis.