Table 4. Regulation of cell growth and proliferation-associated genes in the core and periinfarct after permanent focal cerebral ischemia.
| Symbol | Gene Name | 24 h | 3 d | ||
| Core | Periinfarct | Core | Periinfarct | ||
| Cell Growth and Proliferation | |||||
| CDC2 | Cyclin-dependent kinase 1 | 5.73 (<0.01) | 4.17 (<0.05) | 64,5 (<10−9) | 20,1 (<10−5) |
| CDK2 | Cyclin-dependent kinase 2 | – | – | 2,75 (<0.05) | 2.03 (<0.01) |
| MAP2 | Microtubule-associated protein 2 | – | – | – | – |
| CDK5R1 | Cyclin-dependent kinase 5,regulatory subunit 1 | – | – | 0.46 (<0.01) | – |
| CCNA2 | Cyclin A2 | 3.95 (0.01) | 3.20 (<0.01) | 33,9 (<10−10) | 10,3 (10−6) |
| CCND1 | Cyclin D1 | 2.48 (<10−4) | 2,00 (<0.01) | 6.15 (<10−9) | 2.79 (10−4) |
| NRP1 | Neuropilin 1 | – | – | 2.07 (<10−7) | – |
| BAI1 | Brain-specific angiogenesis inhibitor 1 | 0.49 (<10−4) | 0.46 (<0.05) | 0.37 (<0.01) | – |
| NDN | Necdin | – | 0.40 (<10−5) | – | – |
| S100A6 | S100A6 gene | 3.58 (<10−4) | 6.28 (<10−6) | 11,0 (<10−9) | 5.39 (<10−5) |
| INHBA | Inhibin, beta A | 6.77 (<10−4) | – | – | – |
| RUNX3 | Runt-related transcription factor 3 | – | – | – | – |
| MAP4K1 | Mitogen-activated protein kinase 1 | – | – | 4.69 (<10−7) | 2.03 (<0.05) |
| RHOH | Ras homolog gene family, member H | 2.08 (<0.05) | 2.11 (<0.05) | 6.54 (<10−7) | 2.95 (<0.01) |
| VEGFA | Vascular endothelial growth factor A | – | – | – | – |
| VEGFB | Vascular endothelial growth factor B | – | – | – | – |
| VEGFC | Vascular endothelial growth factor C | 0.42 (<10−8) | – | – | – |
| FGF13 | Fibroblast growth factor 13 | 0.47 (<10−5) | 0.46 (<10−5) | 0.33 (<10−8) | – |
| GNAO1 | Guanine nucleotide binding protein | – | – | – | – |
Expression is given by fold change in value compared with healthy controls. Adjusted p-value (AdjP) is given in parenthesis.