Table 5. Regulation of nervous system development and function-associated genes in the core and periinfarct after permanent focal cerebral ischemia.

Symbol	Gene Name	24 h		3 d
		Core	Periinfarct	Core	Periinfarct
Nervous System Dev. & Function
SYN1	Synapsin I	–	0.40 (<10−5)	0.42 (<10−5)	–
TF	Transferrin	2.16 (<0.01)	–	2.68 (<10−5)	2.11 (<0.01)
LINGO1	Leucine rich repeat and Ig domain containing 1	–	0.44 (<10−4)	0.33 (<10−5)	–
RTN4 (NOGO)	Reticulon-4	0.44 (<0.01)	0.34 (<10−4)	0.35 (<10−4)	0.49 (<0.05)
RTN4R	Reticulon-4 receptor	0.50 (<10−4)	0,.40 (<10−5)	0.39 (<10−6)	–
BMP4	Bone morphogenetic protein-4	0.40 (<10−5)	0.43 (<10−4)	–	–
BMP7	Bone morphogenetic protein-7	–	–	2.39 (<10−5)	–
GRN	Granulin	–	–	10.3 (<10−11)	4.76 (<10−6)
GRIN1	Glutamate [NMDA] receptor subunit zeta-1	–	0.49 (<10−5)	0.41 (<10−7)	–
ROBO2	Roundabout, axon guidance receptor, homolog 2	–	0.49 (<10−4)	0.46 (<10−5)	–
GFAP	Glial fibrillary acidic protein	7.52 (<10−6)	10.1 (<10−7)	11.5 (<10−8)	9.19 (<10−6)
FGF2	Fibroblast growth factor 2	3.65 (<10−8)	3.94 (<10−8)	–	2.16 (<10−4)
HB-EGF	Heparin-binding EGF-like growth factor	4.23 (<10−5)	3.41 (<10−4)	–	–
TGFB1	Transforming growth factor, beta 1	3.61 (<10−4)	2.71 (<0.01)	8.81 (<10−8)	3.61 (<10−4)
TGFB2	Transforming growth factor, beta 2	3.05 (<10−10)	–	–	–
BDNF	Brain-derived neurotrophic factor	2.66 (<0.05)	–	0.27 (<0.01)	–
NTF4	Neurotrophin 4	2.27 (<0.01)	3.81(<10−6)	–	–
ARTN	Artemin	2.81 (<0.01)	–	–	–
YWHAH	14-3-3 protein eta	–	0.47 (<10−4)	–	–
PTN (NEGF1)	Pleiotropin	–	–	–	–
NRCAM	Neuronal cell adhesion molecule	–	0.44 (<10−5)	0.41 (<10−6)	–
DCX	Doublecortin	–	–	0.50 (<10−4)	–
NUMB	Protein numb homolog	–	–	–	–
DPYSL3	DPY-related protein 3	–	–	2.14 (<10−4)	–

Expression is given by fold change in value compared with healthy controls. Adjusted p-value (AdjP) is given in parenthesis.