Table 6. Regulation of DNA replication, recombination & repair and also cell death-associated genes in the core and periinfarct after permanent focal cerebral ischemia.
| Symbol | Gene Name | 24 h | 3 d | ||
| Core | Periinfarct | Core | Periinfarct | ||
| DNA Replication Recomb. & Repair | |||||
| ADA | Adenosine deaminase | – | 2.64 (<0.01) | 6.19 (<10−7) | 3.12 (<0.01) |
| RPA1 | Replication protein A1 | – | 0.47 (<0.01) | – | – |
| CDT1 | DNA replication factor CDT1 | 4.76 (<10−4) | 3.58 (<0.01) | 11.6 (<10−7) | 4.00 (<0.01) |
| E2F3 | Transcription factor E2F3 | – | 2.01 (<10−4) | – | – |
| EXO1 | Exonuclease 1 | 3.53 (<10−4) | 2.99 (<10−4) | 13.1 (<10−10) | 4.44 (<10−5) |
| Cell Death | |||||
| CASP3 | Caspase 3 | 2.43 (<10−6) | – | – | – |
| CASP9 | Caspase 9 | 2.13 (<0.05) | 0.32 (<10−4) | 0.43 (<0.01) | – |
| BCL2 | B-cell lymphoma 2 | – | 0.49 (<0.01) | – | – |
| AIFM3 | Apoptosis-inducing factor, mitochondrion-associated 3 | 0.32 (<106) | 0.34 (<105) | 0.30 (<107) | – |
| BID | BH3 interacting-domain death agonist | – | – | – | – |
| CASP8 | Caspase 8 | – | – | 4.23 (<10−4) | – |
| BIRC5 | Survivin | – | – | 13.1 (<10−10) | 4.17 (<10−4) |
| ADORA1 | Adenosine A1 receptor | – | 0.47 (<0.01) | – | – |
| HSP27 (HSP18) | Heat shock protein 27 | 43.1 (<10−9) | 48.8 (<10−10) | 15.6 (<10−7) | 9.78 (<10−5) |
| HSPA1A (HSP72) | Heat shock 70 kDa protein 1 | 52.0 (<10−12) | 81.6 (<10−14) | 2.56 (<0.01) | – |
| HSPA1B | Heat shock 70 kDa protein 1B | 73.5 (<10−16) | 129 (<10−18) | 2.66 (<10−4) | – |
| HSPA2 | Heat shock-related 70 kDa protein 2 | 3.09 (<10−8) | 3.03 (<10−7) | – | – |
| HSPA8 (HSC70) | Heat shock 70 kDa protein 8 | – | – | – | – |
| HSPA9 (GPR75) | Heat shock 70 kDa protein 9 | – | 2.25 (<10−7) | – | – |
Expression is given by fold change in value compared with healthy controls. Adjusted p-value (AdjP) is given in parenthesis.