Table 7. Regulation of cellular assembly & organization and cell signaling-associated genes in the core and periinfarct after permanent focal cerebral ischemia.
Symbol | Gene Name | 24 h | 3 d | ||
Core | Periinfarct | Core | Periinfarct | ||
Cellular Assembly & Organization | |||||
RHOA | Ras homolog gene family, member A | – | – | – | – |
SMC4 | Structural maintenance of chromosomes 4 | – | – | 3.83 (<10−9) | 2.02 (<10−4) |
NUF2 | Kinetochore protein Nuf2 | – | – | 19.7 (<10−9) | 7.36 (<10−5) |
ECT2 | ECT2 gene | 3.16 (<0.05) | – | 32.0 (<10−10) | 10.6 (<10−5) |
FEZ1 | Fasciculation and elongation protein zeta-1 | – | – | 0.45 (<0.01) | – |
TNR | Tenascin-R | – | – | 0.47 (<10−7) | – |
Cell Signaling | |||||
RFTN1 | Raftlin, lipid raft linker 1 | 2.12 (<0.01) | 2.45 (<10−4) | 7.06 (<10−9) | 2.29 (<0.01) |
NDN | Necdin | – | 0.40 (<10−5) | – | – |
CCL5 | Chemokine (C-C motif) ligand 5 | – | 2.39 (<0.05) | 2.36 (<0.01) | – |
CXCL1 | Chemokine (C-X-C motif) ligand 1 | 27.1 (<0.01) | 238 (<10−6) | 82.7 (<10−5) | 27.7 (<0.01) |
CXCL10 | Chemokine (C-X-C motif) ligand 10 | 7.36 (<10−4) | 9.38 (<10−4) | 6.27 (<10−4) | 9.32 (<10−4) |
CXCL11 | Chemokine (C-X-C motif) ligand 11 | 11.5 (<10−4) | 22.8 (<10−5) | 25.3 (<10−6) | 12.8 (<10−4) |
CXCL12 (T1) | Chemokine (C-X-C motif) ligand 12 (transcript 1) | – | – | – | – |
CXCL12 (T3) | Chemokine (C-X-C motif) ligand 12 (transcript 3) | 0.28 (<10−9) | 0.36 (<10−7) | – | – |
CXCL13 | Chemokine (C-X-C motif) ligand 13 | 4.75 (<0.05) | 3.48 (<0.05) | 10.9 (<10−5) | 5.89 (<0.05) |
CCL2 | Chemokine (C-C motif) ligand 2 | 576 (<10−8) | 560 (<10−8) | 388 (<10−8) | 69.1 (<10−5) |
CCL4 | Chemokine (C-C motif) ligand 4 | 15.8 (<10−7) | 14.0 (<10−7) | 7.94 (<10−6) | 2.88 (<0.05) |
CCL5 | Chemokine (C-C motif) ligand 5 | – | 2.39 (<0.05) | 2.36 (<0.01) | – |
CCL20 | Chemokine (C-C motif) ligand 20 | 46.2 (<10−5) | 90,5 (<10−6) | 4.86 (<0.05) | – |
MyD88 | Myeloid differentiation primary response gene 88 | 2.27 (<0.01) | 2.00 (<0.05) | 2.71 (<10−4) | – |
ANGPT2 | Angiopoietin-2 | 3.41 (<0.05) | 2.92 (<0.05) | 2.36 (<0.05) | – |
CALCB | Calcitonin-related polypeptide beta | 18.4 (<10−8) | 12.2 (<10−6) | 61.8(<10−11) | 11.8 (<10−6) |
Expression is given by fold change in value compared with healthy controls. Adjusted p-value (AdjP) is given in parenthesis.