Figure 1. Detailed outline describing the creation of the normalized adjacency matrices (NAM) and fold-specific combined adjacency matrix (f-CAM) using a set of toy peptides PIAHT and PTYEVF.

The ij^th position/s in the f-CAM which has hub-weight greater than 1 is highlighted in red circles. This particular interaction/edge (between position 7 and 8 in the toy example) is a conserved interaction in both the peptides.