Table 4. “Fold-specific hot spot” residues obtained from a combination of all four and either of the three network parameters (derived from “Fold-specific hot spot” positions) for one representative member of each family.

Positions	CheY	Family1	Family2	Family3	Family4	Family5	Family6	Family7	Family8
136	L8	A32	I6	T5	V36	A5	G4	L28	I4
137	V9	V33	V7	I6	I37	V6	V5	V29	I5
139	V10	F34	Y8	L7	L38	I7	V6	V30	A6
141	D11	G35	G9	G8	G39	G8	G7	G31	G7
151	R17	G40	G15	G14	G44	G13	G12	G36	G12
155	V20	A43	I18	T17	A47	L16	L15	V39	L15
156	R21	I44	L19	L18	A48	A17	A16	A40	A16
193	A35	V58	I32	V34	F61	E32	V29	A54	I29
425	F52	Y100	G74	Q96	L98	M72	I60	V87	M68
427	I54	V102	F76	M98	I100	V74	F62	V89	I70
428	S55	E103	C77	A99	G101	I75	I63	S90	A71
429	D56	C104	V78	A100	A102	T76	C64	A91	V72
531	I71	A114	A114	A113	L118	L105	L77	D103	A86
557	P81	V124	L123	T119	V127	I113	I86	L118	K93
558	V82	T125	L124	I120	I128	Y114	V87	I119	T94
560	M84	V127	L126	L122	V129	L116	D89	D121	A96
143	-	L36	K11	T10	G40	A9	L8	A32	I8
159	L24	C47	F22	R22	A51	A20	L19	L43	L19
426	V53	A101	V75	V97	L99	V73	I61	V88	Y69
536	G75	T118	L118	A116	M122	A109	L81	A107	G90
424	G51	D99	D73	D95	D97	D71	K59	D86	D67
133	L5	S29	G3	K2	G33	T2	M1	K25	M1
134	K6	T30	K4	Q3	K34	K3	K2	T26	Y2
135	F7	C31	V5	L4	V35	L4	I3	V27	I3
515	L67	T110	A110	P109	R109	I101	T73	H96	S82

The residues which have been found to be important from previous experimental and theoretical studies are highlighted as bold.