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. 2012 Dec 17;7(12):e51694. doi: 10.1371/journal.pone.0051694

Figure 7. Effects of EpiC treatment on specific-gene promoters.

Figure 7

ChIP experiments, performed on CStC isolated from 2 different patients, show that H3K4Me3 association to (A) c-Kit and (B) MDR-1 promoter is enriched after EpiC treatment, while H3S10P is decreased. Data are expressed as relative enrichment of specific histone modifications i in EpiC-treated cells compared to GM measured by real-time PCR amplification. (C) Real-time RT-PCR analysis of c-Kit and MDR-1 mRNA in EpiC-treated CStC (n = 3, *P≤0.05 and ****P≤0.005).