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. 2012 Dec 17;7(12):e51669. doi: 10.1371/journal.pone.0051669

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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The figure is modified from Fig. 4B in Peirce and Metzger [40]. Square symbols represent FcεRI and the circles represent LAT. The experiment is detailed in Peirce and Metzger [40] and in Materials and Methods of this study. RBL cells were first stimulated with a polyvalent antigen to induce receptor crosslinking and signaling (before time zero in the figure), and then excess monovalent hapten was added (at time zero) to break up the receptor crosslinking. Subsequently, amounts of phosphorylated FcεRI and LAT were assayed at different time points. The figure shows the fraction of phosphorylated FcεRI and LAT remaining after hapten addition.