Table I.
Correlation between HIF-1α expression and clinical parameters in TSCC.
| HIF-1α
|
||||
|---|---|---|---|---|
| Parameter | n (%) | I/II | III/IV | P-value |
| Total | 49 (100) | 27 | 22 | - |
| Gender | 0.158 | |||
| Male | 28 (57.14) | 18 | 10 | |
| Female | 21 (42.86) | 9 | 12 | |
| Age (years) | 0.246 | |||
| <70 | 21 (42.86) | 14 | 7 | |
| ≥70 | 28 (57.14) | 13 | 15 | |
| Neck dissection | 0.395 | |||
| Yes | 30 (61.22) | 15 | 15 | |
| No | 19 (38.78) | 12 | 7 | |
| T stage | 0.010a | |||
| T1 + Tis | 24 (48.98) | 18 | 6 | |
| T2 + T3 | 25 (51.02) | 9 | 16 | |
| Lymphatic metastasis | 0.005a | |||
| Negative | 43 (87.76) | 27 | 16 | |
| Positive | 6 (12.24) | 0 | 6 | |
| Histological differentiation | 0.000a | |||
| G1 | 23 (46.94) | 21 | 2 | |
| G2 + G3 | 26 (53.06) | 6 | 20 | |
Data were analyzed using the Chi-square test.
a
P<0.05 was considered to indicate statistically significant differences. HIF-1α, hypoxia-inducible factor-1α; TSCC, tongue squamous cell carcinoma.