Table II.
Correlation of clinical parameters with DFS and OS in TSCC.
| Parameter | DFS (months) | P-value | OS (months) | P-value |
|---|---|---|---|---|
| Gender | 0.107 | 0.115 | ||
| Male | 33.00±21.96 | 39.93±25.04 | ||
| Female | 26.00±18.99 | 32.48±21.14 | ||
| Age (years) | 0.292 | 0.218 | ||
| <70 | 31.81±20.53 | 39.38±23.60 | ||
| ≥70 | 28.64±21.32 | 34.75±23.675 | ||
| Neck dissection | 0.094 | 0.088 | ||
| Yes | 25.53±20.06 | 31.33±22.561 | ||
| No | 37.05±20.57 | 45.26±22.99 | ||
| T stage | 0.132 | 0.108 | ||
| T1 + Tis | 31.33±20.31 | 39.42±22.58 | ||
| T2 + T3 | 28.72±21.66 | 34.16±24.55 | ||
| Lymphatic metastasis | 0.000b | 0.000b | ||
| Negative | 32.98±20.46 | 40.33±22.78 | ||
| Positive | 8.67±5.20 | 11.00±6.29 | ||
| Histological differentiation | 0.020a | 0.008a | ||
| G1 | 36.35±20.00 | 46.83±21.96 | ||
| G2 + G3 | 24.38±20.28 | 27.81±21.45 | ||
| HIF-1α expression | 0.001a | 0.000b | ||
| Negative/weak | 37.63±20.61 | 46.96±21.85 | ||
| Moderate/strong | 20.64±17.30 | 24.18±19.30 |
Data were analyzed using the log-rank test.
a
P<0.05 was considered to indicate statistically significant differences,
b
P<0.001. DFS, disease-free survival; OS, overall survival; HIF-1α, hypoxia-inducible factor-1α; TSCC, tongue squamous cell carcinoma.