Table 1.

History of immunology research

Innate Immunity	Adaptive Immunity
Discovery of phagocytosis by Metchnikoff (1845–1916) founder of innate immunity(1900)	Serum Therapy by Kitasato and Behring (1890)
	Side-chain theory of antibody by Ehrlich
	Clonal selection by Burnet (1957)
	After 1960’s
	Primary structure of antibodies
	Discovery of IgE and mechanism of allergy
	Discovery of T and B cells
	Discovery of histocompatibility antigens
	Development of monoclonal antibodies
	Mechanism of antibody diversity
After 1996	Cloning of T cell receptor
Role of Drosophila Toll in antifungal response	Cloning of cytokines involved in antibody production
Discovery of mammalian Toll-like receptors (TLRs) and identification of their function	Th1 and Th2 responses
	Identification of molecules involved in antibody diversity