Fig. 1.

Surface recruitment of Na⁺,K⁺-ATPase in correlation with the cleavage and secretion of α-Kl. In α-Kl expressing cells, Na⁺,K⁺-ATPase is recruited to the cell surface by a combination of “the conventional pathway” and “the α-Kl dependent pathway”. Low Ca²⁺ induces the massive recruitment of Na⁺,K⁺-ATPase to the plasma membrane. In contrast, high Ca²⁺ leads to the decline of such additional recruitment. Accordingly, [Ca²⁺]_e regulates this additional recruitment of Na⁺,K⁺-ATPase to the plasma membrane in correlation with the cleavage and secretion of α-Kl.