Table 3.
Common cliques across the four population datasets
| Clique | Enriched GOTerms | Processes(p-value) | Literature of CRC |
|---|---|---|---|
| EGFR, ESR1, GRB2, PTPN6, SHC1, SRC, PIK3R1 | GO:0007173 | EGFR signaling pathway (0.00253) | ESR1 [69] |
| GO:0071363 | Cellular response to growth | GRB2 [49] | |
| GO:0007105 | Signal transduction (0.002) | EEGFR [49] | |
| BRCA1, CREBBP, EP300, ESR1, SMAD2, SMAD3, TP53 | GO:000637 | Regulation of transcription from RNA polymerase II promoter (0.0044) | BRCA1 [73], CREBBP [72] |
| GO:0033993 | Response to lipid (0.00266) |
SMAD2 [48] | |
| GO:0031325 | Positive regulation of cellular metabolic process (0.00048) | P53 [48], EP300 [72] |
|
| CSN2, CSN3, CSN4, CSN5, CSN6, CSN7, CSN8, TP53 | GO:000338 | Protein deneddylation (1.7E-18) | |
| GO:0044267 | Cellular protein metabolic process (0.00029) | ||
| DIS3, EXOSC2, EXOSC4, EXOSC5, EXOSC7, EXOSC8, EXOSC9, MPP6 | GO:0045006 | DNA deamination (9.47E-06) |
EXOSC [81] |
| GO:0006304 | DNA modification (0.00192) | ||
| GO:0006402 | mRNA catabolic process (0.00769) | ||
GO TERM FINDER AND DAVID level 3 (biological processes) were considered for analysis.