Table 3.

FDA-approved drug products in nanometer size range.

	Drug name	Generic Name	Company	Indication	Route of administration	Approved date
Liposomal platforms	Doxil	Doxorubicin HCl Liposome Injection	Ortho Biotech Products, LP	Antineoplastic	i.v.	17-NOV-95
	Abelcet	Amphotericin B Lipid Complex Injection	Enzon Pharmaceuticals	Antifungal	i.v.	20-NOV-95
	DaunoXome	Daunorubicin citrate liposome injection	Diatos	Antineoplastic	i.v.	8-Apr-96
	Amphotec	Amphotericin B Cholesteryl Sulfate Injection	Three Rivers Pharmaceuticals	Antifungal	i.v.	22-NOV-96
	AmBisome	Amphotericin B Liposome Injection	Astellas Pharma US, Inc.	Antifungal	i.v.	11-Aug-97
	Depocyt	Cytarabine Liposome Injection	Enzon Pharmaceuticals	Lymphomatous meningitis	i.t.	1-Apr-99
	Visudyne	Verteporfin for Injection	Novartis	Photodynamic rherapy for aged-related macular degeneration	i.v.	12-Apr-00
Nanocrystal platforms	Rapamune	Sirolimus	Wyeth	Immunosuppressant	Oral	22-Aug-02
	Emend	Aprepitant	Merck & Co., Inc.	Antiemetic	Oral	26-Mar-03
	TriCor	Fenofibrate	Abbott Laboratories	Hypercholesterolemia and hypertriglyceridemia	Oral	5-NOV-04
	Triglide	Fenofibrate	Sciele Pharma, Inc.	Hypercholesterolemia and hypertriglyceridemia	Oral	7-May-05
	Megace ES	Megestrol acetate	Strativa Pharmaceuticals, subsidiary of Par Pharmaceutical. Inc.	Anorexia, cachexia, or an unexplained significant weight loss in AIDS patients	Oral	5-Jul-05
Other platforms	Oncaspar	pegaspargase: pegylated L-asparaginase	Enzon Pharmaceuticals	acute lymphoblastic leukemia	IM or IV	1-Feb-94
	Estrasorb	estradiol topical emulsion	Graceway Pharmaceuticals, LLC	Vasomotot symptoms associated with the menopause	Transdermal	9-Oct-03
	Abraxane	paclitaxel albumin-bound particles for injectable suspension	Abraxis Oncology	Metastatic breast cancer	i.v.	7-Jan-05
	Feridex	femmoxides injectable solution (superparamagnetic iron oxide)	Bayer Healthcare Pharmaceuticals	MRI Contrast Agent	i.v.

Source: Zolnik and Sadrieh, 2009.