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. Author manuscript; available in PMC: 2014 Jan 1.
Published in final edited form as: Hepatology. 2012 Dec 4;57(1):289–298. doi: 10.1002/hep.25958

Figure 1.

Figure 1

Pretreatment of mice with PTEN siRNA (2mg/kg i.v. at −4h) ameliorates liver IRI, compared with untreated or scramble siRNA-treated WT controls (6h of reperfusion after 90min warm ischemia).

(A) The sALT (IU/L) levels. *p<0.0005, n=4–6/group. Mean±SD are shown.

(B) Representative liver histology of ischemic liver lobes: (a) Sham; (b) untreated WT; (c) PTEN siRNA-treatment (d) scramble siRNA-treatment. (H&E staining; magnification ×100, n=4–6/group)

(C) Suzuki’s histological grading of liver IR-damage *p<0.0001, n=4–6/group. Mean±SD are shown.

(D) Liver neutrophil accumulation, assessed by MPO activity (U/gm). *p<0.01, **p<0.005. n=4–6/group. Mean±SD are shown.