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An MMP3 inhibitor blocks E2-mediated FasL cleavage in primary calvarial osteoblasts. Primary murine calvarial osteoblasts were differentiated for 10 days, followed by treatment with vehicle control (EtOH), 10 nM E2 and/or 1 µM MMP3 inhibitor for 24 hours. The conditioned media was removed and subjected to ELISA for FasL. * = p-value <0.01 E2 vs. vehicle, MMP3I and E2+MMP3I. (MMP3I=specific MMP3 inhibitor)
