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. Author manuscript; available in PMC: 2012 Dec 18.
Published in final edited form as: Stem Cells. 2011 Feb;29(2):10.1002/stem.584. doi: 10.1002/stem.584

Figure 3. Avastin blocks cell-induced neovascularization but not BBB repair.

Figure 3

(A) Confocal images showing blood vessel density (BVD) of lectin-stained blood vessels (green) and BBB leakage of biotin (red) at 2 wk after cell or buffer transplantation in animals treated with IgG or Avastin. Scale: BVD:100μm; BBB: 200μm. (B) Quantification revealed that Avastin blocks hCNS-SCns-enhanced vascularization; * p<0.05; ** p<0.01; *** p<0.001 by t-test. N=4 for buffer/Avastin, n=5–8 for all other groups. (C) Avastin did not affect the relative BBB leakage of biotin in cell or buffer animals. N=5 for IgG treated animals; n=3–4 for Avastin-treated animals.