Table 1.

Virtual prediction and the biological effects of lichen depsides and depsidones on the activity of mPGES-1 determined in a cell-free assay.

Comp	Model[a]	Activity[b] [%]	IC50[c] [νm]
1	–	74.6±10.7	>10
2	M2	14.9±4.9	0.43
3	–	60.8±10.7	>10
4	–	75.5±12.9	>10
5	–	73.3±9.7	>10
6	–	89.1±12.5	>10
7	M2	53.9±2.7	>10
8	M1	12.8±3.7	0.4
9	M2	22.1±5.6	1.15
10	–	87.5±13.2	>10

^[a]Pharmacophore models: “M1”= retrieved by pharmacophore model M1; “M2”= retrieved by pharmacophore model M2; “–”= not found by M1 or M2.

^[b]mPGES-1 % remaining activity at 10 μm. Data represent the mean ±SE of n=3–4 independent experiments.

^[c]IC₅₀ against mPGES-1. Values quoted were determined by extrapolation. See the Experimental Section for details.