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Fine structure of a large mossy fiber bouton (MFB) and its postsynaptic element, a proximal dendrite (D) of a CA3 pyramidal cell. The large complex spine (S) establishes synaptic contact (arrow) with the mossy fiber bouton. Arrowheads point to dense-core vesicles. Slice culture of hippocampus following high-pressure freezing, cryosubstitution, and embedding in Epon. Scale bar: 0.5 μm.
