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. 2013 Jan 1;36(1):127–136. doi: 10.5665/sleep.2316

Figure 3.

Figure 3

A: Top: Individual hypnograms of a wild-type (WT) and Cacna1a R192Q (R192Q) mouse during the first 6 h after saline (control) or caffeine injection showing the occurrence of waking (W), non-rapid eye movement (N) sleep, and REM (R) sleep in 1-min intervals. Bottom: Time course of non-rapid eye movement (NREM) sleep after injection with saline (control) or caffeine in wild-type (WT, n = 8) and Cacna1a R192Q mice (R192Q, n = 8). Curves connect mean 1-h values (± SEM) of NREM sleep during the first 6 h after the injection. Significant differences between control and caffeine are indicated by open (WT) or closed (R192Q) triangles (P < 0.05, 2-tailed paired t-test, after significant analysis of variance [ANOVA]). Orientation of triangles indicates the direction of deviation from baseline Asterisks indicate significant differences in NREM sleep between wild-type and Cacna1a R192Q (P < 0.05, 2-tailed t-test after significant ANOVA interaction treatment*genotype). B: Sleep latencies for NREM sleep (left) and REM sleep (right) after saline (Con) and caffeine (Caff) treatment in WT and R192Q mice. Asterisks indicate significant differences between treatment (P < 0.05, 2-tailed paired t-test) or wild-type and Cacna1a R192Q (P < 0.05, 2-tailed t-test after significant ANOVA interaction treatment*genotype P < 0.05).