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Orexin gene transfer into the dorsolateral pontine neurons significantly decreases cataplexy in orexin (ORX) knockout mice. Twenty-one days after recombinant adenoassociated virus (rAAV)-mediated gene transfer sleep and behavior were recorded for 48 h. The data summarize the percent of time spent in cataplexy in 6-h bins. *P < 0.01 versus no rAAV and rAAV-green fluorescent protein (GFP); #P < 0.001 vs. rAAV-GFP; **P < 0.01 versus no rAAV. SEM, standard error of the mean.
