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. 1978 Sep;14(3):327–330. doi: 10.1128/aac.14.3.327

Patient Variables Associated with Penicillin Resistance in Neisseria gonorrhoeae

Clyde Thornsberry 1, Harold W Jaffe 2, Gladys H Reynolds 2, Akbar A Zaidi 2, Paul J Wiesner 2
PMCID: PMC352459  PMID: 101129

Abstract

In an ongoing cooperative study of uncomplicated genital gonorrhea within the United States, 6,735 pretreatment gonococcal isolates were tested for their in vitro resistance to penicillin. By using a regression analysis technique, we examined 99 patient-associated variables which might be associated with penicillin resistance of the isolates. Patients were most likely to have relatively resistant isolates if they were black, had used antimicrobial agents within 2 weeks of treatment for gonorrhea, or were men with symptomatic urethritis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Handsfield H. H., Lipman T. O., Harnisch J. P., Tronca E., Holmes K. K. Asymptomatic gonorrhea in men. Diagnosis, natural course, prevalence and significance. N Engl J Med. 1974 Jan 17;290(3):117–123. doi: 10.1056/NEJM197401172900301. [DOI] [PubMed] [Google Scholar]
  2. Jaffe H. W., Biddle J. W., Thornsberry C., Johnson R. E., Kaufman R. E., Reynolds G. H., Wiesner P. J. National gonorrhea therapy monitoring study: in vitro antibiotic susceptibility and its correlation with treatment results. N Engl J Med. 1976 Jan 1;294(1):5–9. doi: 10.1056/NEJM197601012940102. [DOI] [PubMed] [Google Scholar]
  3. Morello J. A., Lerner S. A., Bohnhoff M. Characteristics of atypical Neisseria gonorrhoeae from disseminated and localized infections. Infect Immun. 1976 May;13(5):1510–1516. doi: 10.1128/iai.13.5.1510-1516.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Phillips I., King A., Warren C., Watts B. The activity of penicillin and eight cephalosporins on Neisseria gonorrhoeae. J Antimicrob Chemother. 1976 Mar;2(1):31–39. doi: 10.1093/jac/2.1.31. [DOI] [PubMed] [Google Scholar]
  5. REYN A., KORNER B., BENTZON M. W. Effects of penicillin, streptomycin, and tetracycline on N. gonorrhoeae isolated in 1944 and in 1957. Br J Vener Dis. 1958 Dec;34(4):227–239. doi: 10.1136/sti.34.4.227. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Wiesner P. J., Handsfield H. H., Holmes K. K. Low antibiotic resistance of gonococci causing disseminated infection. N Engl J Med. 1973 Jun 7;288(23):1221–1222. doi: 10.1056/NEJM197306072882308. [DOI] [PubMed] [Google Scholar]

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