Table 3.

Results of the sparse association methods applied to studying the air particulate matter effects on gene methylations in the asthma pathway in the Normative Aging Study. The estimated loadings of the genes and the exposures are provided, as well as the estimated canonical correlations and the P-values. The P-values were calculated using the proposed permutation and Wilks’ Λ statistic test procedure. All the methods used CIC as the model selection criteria. The last two columns report the P-values of the F-test and the correlation coefficient (R) of individual gene regression on the two exposures.

Gene	SOS-CCA	step-CCA	PMA	ind P-value	ind cor
HLA-DMA	– –	0.31	– –	0.30	0.16
HLA-DPA1	– –	−0.32	– –	0.38	0.15
HLA-DPB1	– –	−0.24	– –	0.64	0.10
HLA-DRA	– –	0.32	– –	0.07	0.24
HLA-DRB5	– –	– –	0.55	*0.01	0.30
FCER1G	−0.47	−0.30	−0.44	*0.01	0.30
IL5	0.50	0.45	0.60	**0.001	0.38
RNASE3	– –	−0.30	– –	0.24	0.18
CCL11	0.58	0.58	0.38	*0.02	0.36
Sulfate	1.01	1.06	0.90	–	–
Black Carbon	−0.04	−0.22	0.42	–	–
Estimated Correlation	0.48	0.61	0.48	–	–
P-value	0.03	0.02	0.01	–	–