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Proposed model of OGP(10-14) differentiation signalling. (A) Control cells: TPO induces M07-e cells proliferation by SFK activation and RhoA inhibition. (B) OGP(10-14)-treated cells: the pentapeptide induces cell differentiation by activating RhoA and preventing SFKs activation through a down-modulation of Mpl induced by an increase of TGFβ1.
