Table 2.
Associations of MSH2, MLH1 and MGMT expression with patients’ age and gender, type of histopathology (Benign vs Malignant thyroid lesions and Hyperplasic nodules vs Papillary carcinomas) and Ki-67 protein statement in 90 thyroid lesions cases.
| Clinicopathological characteristics | MSH2 expression | MLH1 expression | MGMT expression | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Negative/weak (%) | Moderate/strong (%) | p-value | Negative/weak (%) | Moderate/ strong (%) | p-value | Negative/weak (%) | Moderate/ strong (%) | p-value | |
| N=90 | 40 (44) | 50 (56) | 67 (74) | 23 (26) | 24 (27) | 66 (73) | |||
| Age (mean±SD;ys) | 51.6±14.4 | 48.3±15.6 | 0.340 | 51.1±14.3 | 46.1±17.0 | 0.382 | 49.1±14.9 | 50.0±15.3 | 0.701 |
| Gender | 0.019 | 0.434 | 0.176 | ||||||
| Female | 26 (29) | 43 (48) | 50 (56) | 19 (21) | 16 (18) | 53 (59) | |||
| Male | 14 (16) | 7 (8) | 17 (19) | 4 (4) | 8 (9) | 13 (14) | |||
| Histopathology | 0.665 | 0.038 | 0.001 | ||||||
| Benign | 15 (17) | 21 (23) | 31 (34) | 5 (6) | 3 (3) | 33 (37) | |||
| Malignant | 25 (28) | 29 (32) | 36 (40) | 18 (20) | 21 (23) | 33 (37) | |||
| Histopathology (N=70) | 0.228 | 0.014 | 0.026 | ||||||
| Hyperplastic nodules | 14 (20) | 16 (3) | 26 (37) | 4 (6) | 3 (4) | 27 (39) | |||
| Papillary | 13 (19) | 27 (39) | 24 (34) | 16 (23) | 13 (19) | 27 (39) | |||
| Ki-67 protein statement | 0.427 | 0.038 | 0.893 | ||||||
| Negative | 28 (31) | 31 (34) | 48 (53) | 11 (12) | 16 (18) | 43 (48) | |||
| Positive | 12 (13) | 19 (21) | 19 (21) | 12 (13) | 8 (9) | 23 (26) | |||