Table 4.
Associations of MSH2, MLH1 and MGMT expression with clinicopathological characteristics in 54 patients with malignant thyroid lesions.
| Clinicopathological Characteristics | MSH2 expression | MLH1 expression | MGMT expression | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Negative/Weak (%) | Moderate/ Strong (%) | p-value | Negative/Weak (%) | Moderate/ Strong (%) | p-value | Negative/Weak (%) | Moderate/ Strong (%) | p-value | |
| N=54 | 25 (46) | 29 (54) | 36 (67) | 18 (33) | 21 (39) | 33 (61) | |||
| Age (mean ±SD; ys) | 51.9±13.9 | 47.0±15.4 | 0.270 | 50.2±13.9 | 47.4±16.7 | 0.883 | 48.6±14.4 | 49.7±15.2 | 0.570 |
| Tumor size (T) | 0.031 | 0.399 | 0.079 | ||||||
| T1 | 14 (26) | 24 (44) | 24 (44) | 14 (26) | 12 (22) | 26 (48) | |||
| T2-4 | 11 (20) | 5 (9) | 12 (22) | 4 (7) | 9 (17) | 7 (13) | |||
| Lymph node metastasis (N) | 0.518 | 0.184 | 0.309 | ||||||
| N0 | 22 (41) | 27 (50) | 34 (63) | 15 (28) | 18 (33) | 31 (57) | |||
| N1 | 3 (6) | 2 (4) | 2 (4) | 3 (6) | 3 (6) | 2 (4) | |||
| Capsular invasion | 0.949 | 0.094 | 0.616 | ||||||
| No | 20 (37) | 23 (43) | 31 (57) | 12 (22) | 16 (30) | 27 (50) | |||
| Yes | 5 (9) | 6 (11) | 5 (9) | 6 (11) | 5 (9) | 6 (11) | |||
| Lymphatic invasion | 0.794 | 0.006 | 0.522 | ||||||
| No | 20 (37) | 24 (44) | 33 (61) | 11 (20) | 18 (33) | 26 (48) | |||
| Yes | 5 (9) | 5 (9) | 3 (6) | 7 (13) | 3 (6) | 7 (13) | |||
| Vascular invasion | 0.313 | 0.002 | 0.548 | ||||||
| No | 23 (43) | 24 (44) | 35 (65) | 12 (22) | 19 (35) | 28 (52) | |||
| Yes | 2 (4) | 5 (9) | 1 (2) | 6 (11) | 2 (4) | 5 (9) | |||
| Ki-67 protein statement | 0.067 | 0.177 | 0.238 | ||||||
| Negative | 16 (30) | 12 (22) | 21 (39) | 7 (13) | 13 (24) | 15 (28) | |||
| Positive | 9 (17) | 17 (31) | 15 (28) | 11 (20) | 8 (15) | 18 (33) | |||