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SU11652 blocks activation of signal transduction pathways downstream of FLT3. MV-4-11 cells were treated with the indicated concentrations of SU11652 for 24 hours. Cell extracts were subjected to western blot analyses with antibodies against phosphorylated forms of FLT3 (pY591), ERK1/2 (pT202/pY204), Akt (pS473), and STAT5 (pY694). Equal protein loading was demonstrated by blotting with house-keeping gene product GAPDH.
