Table 2.

Biodistribution of radioactivity after concomitant intravenous injection of (+)-[¹²⁵I]IV-OH and (+)-[¹³¹I]pIV in tumor-bearing mice

Analog	Tissue	Time of post-injection
		10 min	1 h	3 h	24 h
(+)-[125I] IV-OH	Blood	1.28 (0.13)*	1.04 (0.10)*	0.43 (0.09)**	0.00 (0.00)*
	Tumor	9.55 (0.64)**	5.45 (0.70)	2.57 (0.41)	0.06 (0.04)**
	Liver	7.82 (0.32)*	9.80 (0.94)**	2.81 (0.33)*	0.06 (0.03)*
	Kidney	35.01 (2.83)*	15.30 (1.80)	4.89 (0.87)**	0.04 (0.01)*
	Intestine	5.26 (0.61)*	7.96 (0.72)*	4.84 (0.95)	0.14 (0.02)*
	Spleen	8.11 (1.24)	1.84 (0.11)*	0.60 (0.12)*	0.01 (0.02)*
	Pancreas	25.04 (2.40)*	12.80 (0.97)*	2.94 (0.49)*	0.01 (0.01)*
	Lung	9.74 (1.59)*	1.85 (0.18)*	0.63 (0.11)*	0.01 (0.02)*
	Heart	3.57 (0.40)*	0.78 (0.05)*	0.27(0.00)**	0.01 (0.01)*
	Stomacha	1.18 (0.36)	0.62 (0.18)	0.55 (0.25)	0.03 (0.02)*
	Brain	5.14 (0.50)*	1.04 (0.08)*	0.22 (0.02)*	0.00 (0.00)*
	Muscle	2.20 (0.58)	0.45 (0.03)*	0.26 (0.10)	0.01 (0.01)*
(+)-[131I]pIV	Blood	0.45 (0.03)	0.28 (0.02)	0.17 (0.01)	0.50 (0.01)
	Tumor	7.20 (0.40)	5.79 (0.37)	6.46 (3.42)	6.81 (2.60)
	Liver	9.83 (0.39)	13.31 (1.25)	13.05 (0.46)	10.28 (0.59)
	Kidney	18.47 (1.59)	11.72 (1.90)	7.37 (0.89)	6.15 (0.30)
	Intestine	4.31 (0.78)	5.14 (0.12)	3.20 (0.13)	2.59 (0.24)
	Spleen	8.12 (1.09)	8.99 (1.00)	4.04 (0.30)	2.52 (0.23)
	Pancreas	16.58 (1.82)	21.94 (2.50)	27.35 (0.24)	27.36 (0.70)
	Lung	26.10 (3.39)	13.13 (3.28)	6.59 (0.56)	3.01 (0.46)
	Heart	8.66 (0.81)	5.55 (0.70)	2.11 (0.37)	0.96 (0.07)
	Stomacha	1.07 (0.32)	0.73 (0.26)	0.62 (0.19)	0.49 (0.06)
	Brain	6.02 (0.74)	6.47 (0.73)	4.12 (0.30)	2.22 (0.10)
	Muscle	2.03 (0.53)	1.62 (0.22)	0.72 (0.29)	0.42 (0.03)

Data are expressed as percent injected dose per gram tissue. Each value represents the mean (SD) for three or four animals. ^aData are expressed as percent injected dose. Significance was determined using paired Student's t test (*p < 0.01 vs. (+)-[¹³¹I]pIV, **p < 0.05).