Table 1.
Summary of subject information presented in Figure6B and C
| Sample no. | Subject | Age | Sex | Post mortem time (min) | Braak stage | Seizure |
Relative ratio (protein/tubulin) |
||
|---|---|---|---|---|---|---|---|---|---|
| Actin | APP | HCN1 | |||||||
| 1 |
Normal |
84 |
F |
877 |
1 |
- |
0.929 |
1.192 |
0.809 |
| 2 |
Normal |
88 |
F |
144 |
1 |
- |
0.856 |
1.046 |
0.859 |
| 3 |
Normal |
70 |
M |
340 |
0.5 |
- |
0.955 |
1.189 |
0.859 |
| 4 |
AD |
84 |
M |
71 |
4 |
- |
0.950 |
1.171 |
0.952 |
| 5 |
AD |
70 |
M |
276 |
4 |
- |
0.829 |
0.986 |
0.716 |
| 6 |
AD |
74 |
M |
322 |
5 |
- |
0.961 |
0.990 |
0.827 |
| 7 |
AD |
75 |
M |
594 |
6 |
- |
1.069 |
1.176 |
0.589 |
| 8 |
AD |
76 |
M |
947 |
6 |
+ |
1.190 |
1.167 |
0.273 |
| 9 |
AD |
79 |
F |
203 |
5 |
- |
1.019 |
0.913 |
0.317 |
| 10 |
AD |
81 |
M |
360 |
6 |
- |
0.971 |
0.862 |
0.247 |
| 11 |
AD |
81 |
F |
442 |
5 |
- |
0.971 |
0.862 |
0.385 |
| 12 |
AD |
82 |
F |
254 |
6 |
- |
0.988 |
1.029 |
0.313 |
| 13 |
AD |
82 |
F |
533 |
5 |
- |
0.988 |
1.001 |
0.566 |
| 14 |
AD |
82 |
F |
338 |
4 |
- |
1.028 |
1.063 |
0.770 |
| 15 |
AD |
84 |
M |
590 |
5 |
- |
1.071 |
1.128 |
0.876 |
| 16 |
Normal |
78 |
F |
87 |
2 |
- |
1.108 |
1.138 |
2.153 |
| 17 |
Normal |
81 |
M |
134 |
1 |
- |
1.122 |
0.971 |
0.902 |
| 18 |
Normal |
82 |
F |
148 |
1 |
- |
1.178 |
1.109 |
1.963 |
| 19 |
Normal |
82 |
F |
155 |
2 |
- |
1.141 |
1.026 |
0.821 |
| 20 |
Normal |
80 |
M |
317 |
2 |
- |
1.254 |
1.037 |
0.893 |
| 21 |
Normal |
80 |
M |
510 |
2 |
- |
1.071 |
0.778 |
0.669 |
| 22 |
Normal |
82 |
M |
530 |
1 |
- |
0.979 |
0.916 |
0.384 |
| 23 |
Normal |
78 |
M |
575 |
1 |
- |
0.905 |
1.007 |
0.713 |
| 24 |
Normal |
78 |
M |
690 |
1 |
- |
0.784 |
0.986 |
1.479 |
| 25 | Normal | 82 | M | 736 | 1 | - | 0.774 | 0.743 | 1.448 |
Postmortem brain samples were obtained from the Brain Bank for Aging Research, Tokyo Metropolitan Institute of Gerontology. Experimental procedures were approved by the appropriate ethical boards at each institute. Autopsies were performed with written informed consent from the patients or their relatives. The clinical diagnosis of AD was based on two major criteria: the Diagnostic and Statistical Manual of Mental Disorders: 4th Edition (DSM-IV) and the National Institute of Neurological and Communicational Disorders and Stroke-Alzheimer's Disease and Related Disorders Association (NINCDS-ADRDA). The neuropathological diagnosis of AD was made using Consortium to Establish a Registry for Alzheimer’s Disease criteria (average age at death, 79.2 ± 4.4 years). Control brains were obtained from age-matched individuals with no history of neurological or psychiatric illness (average age at death, 80.4 ± 4.2 years). Subjects, age, gender, postmortem time, Braak stage, seizure history, and relative protein/tubulin ratios are indicated.