Fig. 6.

Estimated effects of diplotype substitutions at QTL. For each phenotype-QTL combination, shaded matrix indicates the estimated effect on the transformed phenotype of a given founder haplotype combination. Side bars show the scale of the phenotype (e.g., body weight varies from 202 to 464 g) and the scale of the effects, such that, e.g., for an otherwise average body weight, diplotype substitutions could push the phenotype anywhere from 296 to 374 g. The transformed value of the phenotypes, as described in methods, is used. These estimates act as a rough guide to the relative effects of substitution, with the order of closely ranked contrasts being highly sensitive to sampling error. In particular, the average standard error of estimates reported here was 0.166 (fasting glucose: D1Rat168-D1Rat70), 0.284 (Insulin_AUC: D1Rat181-D1Arb24), 0.0701 (fasting insulin: D1Mgh10-D1Rat168), 0.397 (QUICKI: D1Mgh10-D1Rat168), 0.140 (fasting insulin: D1Rat291-D1Rat218), 0.751 (QUICKI: D1Rat291-D1Rat218), and 27.4 (body weight: D1Rat302-D1Got225).