Table 5.
An overview of the amino acid sequence similarity of the main subfamilies of C. elegans and D. melanogaster rhodopsin GPCRs and their human homologs.
| Rhodopsin | Subfamily | Characterized with function assigned |
Novel members with an unknown role in feeding |
||
|---|---|---|---|---|---|
| C. elegans (%) | D. melanogaster (%) | C. elegans (%) | D. melanogaster (%) | ||
| α-Group | Gastrin-cholecystokinin | 32–36 | 33–37 | ||
| β-Group | Neurokinin/neuropeptide FF/Orexin | 38–43 | 27–45 | 30–38 | 27–33 |
| Neuropeptide Y | 32–40 | 12–36 | 29–41 | 12–14 | |
| Bombesin | 38–40 | ||||
| Neuromedin U | 35–41 | 29–41 | 30–36 | 21–25 | |
| γ-Group | Somatostatin | 35–41 | 27–35 | ||
| Galanin | 36–40 | 37–43 | |||
Percentage of sequence similarity was calculated in the GeneDoc program (http://www.nr.bsc.org/gfx/genedoc/). The maximum and minimum sequence similarity of receptor subgroups between invertebrate and human homologs is indicated.