TABLE 2.

Anatomic Parameters Used in the Monkey PBPK Models

Dimension (tissue/region)	Compartment 1 (mucus + epithelium)a	Compartment 2 (subepithelium)b
Compartment surface area (cm2)c
Nose; squamous (vestibule)	2.0	2.0
Nose; respiratoryd	15.7	15.7
Nose; olfactory	3.4	3.4
Larynx	1.7	1.7
Trachea	7.2	7.2
Main bronchi	4.0	4.0
Secondary bronchi + bronchioles	105.1	105.1
Compartment thickness (cm)
Nose; squamous (vestibule)e	0.0050	0.0015
Nose; respiratoryd,e	0.0070	0.0020
Nose; olfactoryd	0.0070	0.0020
Larynx	0.0065	0.0015
Trachea	0.0066	0.0015
Main bronchi	0.0066	0.0015
Secondary bronchi + bronchioles	0.0066	0.0015

^aCompartment 1 consists of both mucus and epithelium. Except where otherwise noted, the thickness of the mucus and epithelial layer in each compartment was assumed to be the same as the human (see Table 1).

^bThe subepithelial compartment consists of connective tissue, capillaries, glands, macrophages, lymph vessels, etc. just below the epithelium as defined by ICRP (1994). This compartment receives the cardiac output in the model from Table 4.

^cComputed from CFD model surface.

^dRespiratory region in the CFD/PK models for the rat and human defined by Schroeter et al. (2008) also includes the transitional and lymphoepithelium; this designation was maintained in the current monkey model.

^eFrom Carey et al. (2007).