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The proposed pathway of activation of specific CD8+ T cells following prime-boost vaccination and infection (based on Vasconcelos et al., 2012). Prime-boost regimen was performed as detailed described by Rigato et al. (2011). Mice were primed i.m. with plasmid DNA (100 µg) and boosted 21 days later with AdHu5 (2 × 108) both expressing the gene encoding the amastigote surface protein-2 of T. cruzi. Mice were infected s.c. with T. cruzi (150 blood stream trypomastigotes).
