Table 2.

Expression profiling of ischaemic myocardium in animal models.

Target tissue	Experimental treatment	Number of genes affected
Rabbit heart [29]	Two five-minute episodes of ischaemia followed by five hours of reperfusion	Strong upregulation of MAPKAPK-3
Rat hearts [30,31]	20-minute episode of ischaemia followed by four hours of reperfusion	Significant upregulation of HSP-27 and 70
Rat in vivo myocardial infarction model [32]	Permanent coronary occlusion	731 differentially expressed genes
Rats' hearts [33]	Administration of angiotensin-converting enzyme (ACE) inhibitor	37 genes clustered into 11 functional groups, ACE inhibition after myocardial infarction inhibits cardiac hypertrophy
Rats' heart [34]	Ligation of the left anterior descending coronary artery	Expression of genes associated with a foetal transcription programme