Table 2.
Synthesis of Pentafluorophenyl Oxiranes.
![]() | |||
---|---|---|---|
Entry | Ketone 1 | Product 2 | Yield, %[a] (dr) |
1 |
1a
![]() |
2a
![]() |
92 90[b] |
2 |
1b
![]() |
2b
![]() |
>99 |
3 |
1c
![]() |
2c
![]() |
74 |
4 |
1d
![]() |
2d
![]() |
70 |
5 |
1e
![]() |
2e
![]() |
66 |
6 |
1f
![]() |
2f
![]() |
88 |
7 |
1g
![]() |
2g
![]() |
65 |
8 |
1h
![]() |
2h
![]() |
82 |
9 |
1i
![]() |
2i
![]() |
53 |
10 |
1j
![]() |
2j
![]() |
62 |
11 |
1k
![]() |
2k
![]() |
60 |
12 |
1l
![]() |
2l
![]() |
81 (95:5) 90 (95:5) [c] |
13 |
1m
![]() |
2m
![]() |
85 (93:7) |
Isolated yields of 0.5 mmol reactions.
Reaction was in toluene medium.
A 10 mmol reaction in toluene.