Table 3.
Table 3a. Genes with Gene symbol expression levels specifically associated with the cytotoxicity of perifosine (FDRBH < 0.10)
| Gene symbol | Gene title | ra | p | Response | |
|---|---|---|---|---|---|
| GL-U95 | |||||
| REG4 | Regenerating islet-derived family, member 4 | -0.58 | I.3E-06 | Sensitivity | |
| SLCO4A1 | Solute carrier organic anion transporter family, member 4A1 | -0.52 | 2.3E-05 | Sensitivity | |
| RPL18A | Ribosomal protein L18a | -0.50 | 4.7E-05 | Sensitivity | |
| OAZ2 | Ornithine decarboxylase antizyme 2 | 0.53 | I.6E-05 | Resistance | |
| DZIP3 | Zinc finger DAZ-interacting protein 3 | 0.58 | I.5E-06 | Resistance | |
| NP-U95 | |||||
| STK39 | Serine threonine kinase 39 (STE20/ SPSI homologue, yeast) | - 0.48 | I.2E-04 | Sensitivity | |
| FAM32A | Family with sequence similarity 32, member A | - 0.46 | 2.5E-04 | Sensitivity | |
| MAPKAPK3 | Mitogen-activated protein kinase-activated protein kinase 3 | - 0.45 | 3.0E-04 | Sensitivity | |
| RAB8A | RAB8A, member Ras oncogene family | - 0.44 | 4.7E-04 | Sensitivity | |
| STK17B | Serine/threonine kinase I7b (apoptosis-inducing) | - 0.44 | 5.8E-04 | Sensitivity | |
| TCF3 | Transcription factor 3 (E2A immunoglobulin enhancer binding factors EI2/E47) | - 0.44 | 5.8E-04 | Sensitivity | |
| PARP4 | Poly (ADP-ribose) polymerase family, member 4 | - 0.43 | 6.IE-04 | Sensitivity | |
| PSMA2 | Proteasome (prosome, macropain) subunit, alpha type, 2 | - 0.43 | 6.3E-04 | Sensitivity | |
| DGKE | Diacylglycerol kinase, epsilon 64 kDa | - 0.43 | 6.9E-04 | Sensitivity | |
| PVT1 | Pvtl oncogene homologue, MYC activator (mouse) | 0.42 | I.0E-03 | Resistance | |
| ELOVL2 | Elongation of very long chain fatty acids (FENI/Elo2, SUR4/Elo3, yeast)-like 2 | 0.42 | 9.5E-04 | Resistance | |
| SMARCA3 | SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily a, member 3 | 0.42 | 9.3E-04 | Resistance | |
| USP6 | TLI32 protein | 0.43 | 7.IE-04 | Resistance | |
| IGF1R | Insulin-like growth factor I receptor | 0.44 | 5.3E-04 | Resistance | |
| NFATC4 | Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 | 0.44 | 5.4E-04 | Resistance | |
| POU4F1 | POU domain, class 4, transcription factor I | 0.44 | 5.IE-04 | Resistance | |
| PDLIM3 | PDZ and LIM domain 3 | 0.44 | 5.0E-04 | Resistance | |
| CBS | Cystathionine beta-synthase | 0.44 | 4.4E-04 | Resistance | |
| ARMCX2 | Armadillo repeat containing, X-linked 2 | 0.45 | 3.9E-04 | Resistance | |
| OPHN1 | Oligophrenin I | 0.46 | 2.5E-04 | Resistance | |
| ZNF609 | Zinc finger protein 609 | 0.46 | 2.3E-04 | Resistance | |
| ATN1 | Atrophin I | 0.47 | I.5E-04 | Resistance | |
| DZIP3 | Zinc finger DAZ-interacting protein 3 | 0.48 | I.3E-04 | Resistance | |
| PPBPL2 | Pro-platelet basic protein-like 2 | 0.49 | 9.3E-05 | Resistance | |
| MPDZ | Multiple PDZ domain protein | 0.53 | I.3E-05 | Resistance | |
| SKIV2L | Superkiller viralicidic activity 2-like (Saccharomyces cerevisiae) | 0.56 | 4.6E-06 | Resistance | |
| GABRG3 | Gamma-aminobutyric acid (GABA) A receptor, gamma 3 | 0.60 | 4.9E-07 | Resistance | |
| NS-cDNA | |||||
| ATF2 | Activating transcription factor 2 | - 0.56 | 4.8E-06 | Sensitivity | |
| TRA2A | Transformer-2 alpha | - 0.44 | 8.3E-04 | Sensitivity | |
| ETS2 | V-ets erythroblastosis virus E26 oncogene homologue 2 (avian) | - 0.44 | 5.3E-04 | Sensitivity | |
| UBE2D3 | Ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homologue, yeast) | - 0.42 | 8.5E-04 | Sensitivity | |
| ANP32A | Acidic (leucine-rich) nuclear phosphoprotein 32 family, member A | 0.49 | I.6E-04 | Resistance | |
| Table 3b. SNPs associated with the cytotoxicity of perifosine (FDRBH < 0.10) | |||||
| dbSNPa | Gene locus | Location | r | p | Model |
| rs4236669 | CACNA2DI | Intron | 0.64 | 2.8E-07 | Recessive |
| rsl468400 | CACNA2DI | Intron | 0.62 | 8.8E-07 | Recessive |
| rs1345938 | EXOC4 | Intron | 0.58 | 2.6E-06 | Recessive |
Table 3a. aPearson correlation coefficients were calculated by linear regression in which cytotoxicity (-log10[GI50]) was dependent on gene expression. A positive r-value indicates that a gene is correlated with resistance, while a negative r-value indicates that a gene is correlated with sensitivity.
Table 3b. adbSNP Build 126 (May, 2006).