Supplementary Table 2.
Genes whose expression levels were associated with the cytotoxicity of perifosine (FDRBH < 0.10) but were not perifosine specific
| Symbol | Gene title | r | p | Control totala |
|---|---|---|---|---|
| GL-U95 | ||||
| FNBP3 | Formin-binding protein 3 | -0.53 | 3.5E-05 | 75 |
| MOBKL2A | MOBI, Mps One Binder kinase activator-like 2A (yeast) | -0.50 | 5.5E-05 | 43 |
| TP53INP2 | Tumour protein p53 inducible nuclear protein 2 | 0.51 | 3.9E-05 | 24 |
| FBXO44 | F-box protein 44 | 0.52 | 2.4E-05 | 53 |
| TMF1 | TATA element modulatory factor 1 | 0.53 | 1.7E-05 | 57 |
| NP-U95 | ||||
| HNRPDL | Heterogeneous nuclear ribonucleoprotein D-like | -0.49 | 6.9E-05 | 3 |
| DDX39 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 39 | -0.49 | 7.3E-05 | 22 |
| MRPL23 | Mitochondrial ribosomal protein L23 | -0.49 | 8.7E-05 | 2 |
| RPS24 | Ribosomal protein S24 | -0.47 | 1.9E-04 | 21 |
| LBR | Lamin B receptor | -0.47 | 2.0E-04 | 73 |
| ERCC5 | Excision repair cross-complementing rodent repair deficiency, complementation group 5 | -0.47 | 2.0E-04 | 11 |
| HDAC1 | Histone deacetylase 1 | -0.46 | 2.2E-04 | 2 |
| GTF3A | General transcription factor IIIA | -0.45 | 3.IE-04 | 11 |
| EEF1B2 | Eukaryotic translation elongation factor 1 beta 2 | -0.44 | 4.3E-04 | 68 |
| ICAM3 | Intercellular adhesion molecule 3 | -0.44 | 5.IE-04 | 43 |
| SNRPF | Small nuclear ribonucleoprotein polypeptide F | -0.44 | 5.2E-04 | 83 |
| SH2D1A | SH2 domain protein IA, Duncan's disease (lymphoproliferative syndrome) | -0.44 | 5.8E-04 | 61 |
| KIR3DL1 | Killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1 | -0.43 | 7.3E-04 | 76 |
| RPL35 | Ribosomal protein L35 | -0.42 | 8.IE-04 | 47 |
| NUPL2 | Nucleoporin-like 2 | -0.42 | 8.8E-04 | 1 |
| PTMA | Prothymosin, alpha (gene sequence 28) | -0.42 | 9.0E-04 | 33 |
| CORO1A | Coronin, actin-binding protein, IA | -0.42 | 9.3E-04 | 104 |
| LCNI | Lipocalin 1 (tear prealbumin) | -0.42 | 9.3E-04 | 21 |
| POLE3 | Polymerase (DNA directed), epsilon 3 (pl7 subunit) | -0.42 | 9.2E-04 | 31 |
| RPS27A | Ribosomal protein S27a | -0.42 | 9.4E-04 | 79 |
| TRIMI4 | Tripartite motif-containing 14 | -0.42 | 9.3E-04 | 60 |
| LHFPL2 | Lipoma HMGIC fusion partner-like 2 | 0.42 | l.0E-03 | 99 |
| DOK5 | Docking protein 5 | 0.42 | 9.5E-04 | l |
| EIF4GI | Eukaryotic translation initiation factor 4 gamma, l | 0.42 | 9.6E-04 | 28 |
| RGSI9 | Regulator of G-protein signalling 19 interacting protein l | 0.42 | 9.2E-04 | 116 |
| COPB2 | Coatomer protein complex, subunit beta 2 (beta prime) | 0.42 | 8.9E-04 | l |
| TLE2 | Transducin-like enhancer of split 2 (E(spl) homologue, Drosophila) | 0.42 | 9.0E-04 | 4 |
| ITGA7 | Integrin, alpha 7 | 0.42 | 8.6E-04 | 13 |
| SEMA3C | Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.42 | 8.2E-04 | 22 |
| SI00AI3 | S100 calcium binding protein A13 | 0.43 | 7.8E-04 | 88 |
| FLOTI | Flotillin 1 | 0.43 | 6.5E-04 | 2 |
| MLFI | Myeloid leukemia factor 1 | 0.43 | 6.0E-04 | 11 |
| ARHGEFII | Rho guanine nucleotide exchange factor (GEF) 11 | 0.44 | 5.5E-04 | 9 |
| COLI5AI | Co11agen, type XV, alpha l | 0.44 | 4.9E-04 | l |
| DAGI | Dystroglycan l (dystrophin-associated glycoprotein l) | 0.44 | 4.9E-04 | 118 |
| IFNAI4 | Interferon alpha l4 | 0.44 | 4.8E-04 | 2 |
| PHLDBI | Pleckstrin homology-like domain, family B, member l | 0.44 | 4.5E-04 | 12 |
| PTPRS | Protein tyrosine phosphatase, receptor type S | 0.45 | 4.0E-04 | 2 |
| SASHI | SAM and SH3 domain containing l | 0.45 | 4.lE-04 | 52 |
| ACVRIB | Activin A receptor, type IB | 0.45 | 3.2E-04 | 18 |
| CTNNAI | Catenin (cadherin-associated protein), alpha 1, 102 kDa | 0.46 | 3.0E-04 | 30 |
| IL6ST | Interleukin 6 signal transducer (gp130, oncostatin M receptor) | 0.46 | 2.9E-04 | 68 |
| ATP6VID | ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D | 0.46 | 2.5E-04 | 2 |
| SUOX | Sulphite oxidase | 0.46 | 2.1E-04 | 58 |
| TFAP2A | Transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) | 0.48 | 1.3E-04 | 51 |
| GRINA | Glutamate receptor, ionotropic, N-methyl D-asparate-associated protein 1 (glutamate binding) | 0.49 | 9.3E-05 | 1 |
| ABCB6 | ATP-binding cassette, sub-family B (MDR/ TAP), member 6 | 0.49 | 8.2E-05 | 8 |
| CTSF | Cathepsin F | 0.49 | 7.4E-05 | 9 |
| VEGFB | Vascular endothelial growth factor B | 0.50 | 4.6E-05 | 6 |
| GGCX | Gamma-glutamyl carboxylase | 0.52 | 2.1E-05 | 23 |
| LAPTM4B | Lysosomal-associated protein transmembrane 4 beta | 0.53 | 1.6E-05 | 84 |
| FYN | Sialidase 1 (lysosomal sialidase) | 0.55 | 6.3E-06 | 59 |
| NS-cDNA | ||||
| LBR | Lamin B receptor | -0.47 | 1.3E-04 | 1 |
| TRA2A | Transformer-2 alpha | -0.44 | 8.3E-04 | 13 |
| ETS2 | V-ets erythroblastosis virus E26 oncogene homolog 2 (avian) | -0.44 | 5.3E-04 | 30 |
| UBE2D3 | Ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homologue, yeast) | -0.42 | 8.5E-04 | 4 |
| RRMI | Ribonucleotide reductase M1 polypeptide | -0.41 | 9.8E-04 | 1 |
| ATP6VICI | ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C, isoform 1 | 0.42 | 7.7E-04 | 51 |
| VEGFB | Vascular endothelial growth factor B | 0.44 | 6.3E-04 | 57 |
| RDX | Radixin | 0.45 | 4.2E-04 | 29 |
| APOD | Apolipoprotein D | 0.45 | 3.1E-04 | 3 |
| PTMS | Parathymosin | 0.47 | 1.8E-04 | 2 |
aThe total number of associated standard agents (see Methods).