Table 2.

Association analysis of eight cystolic aldehyde dehydrogenase (ALDH1A1) polymorphisms with AUDIT score

Variant	Chromosomal location (bp)a	Gene location	Allelesb		MAFc	Allelic AUDIT score meansd		Genotypic AUDIT score meanse			Genotypic association (p value)		Mode of inheritance
			Allele 1	Allele 2		Allele 1	Allele 2	1/1	1/2	2/2	Generalf	Best modelg
rs348479	74702120	3' UTR	G	T	0.177	17.79	19.66	11.00	19.47	19.33	0.08	0.025	Dominant
rs348472	74710880	Intron 1 1	A	G	0.035	20.67	19.30	28.00	18.90	19.08	0.75	0.44	Dominant
rs610529	74723144	Intron 8	A	G	0.399	20.21	17.85	20.50	19.07	14.65	0.027	0.013	Recessive
rs2288087	74733858	Intron 4	A	T	0.475	18.94	19.71	17.53	19.61	19.34	0.48	0.23	Dominant
rs13959	74735702	Exon 3	A	G	0.472	19.65	19.00	19.34	19.48	17.83	0.62	0.33	Recessive
rs348449	74744802	Intron 2	A	G	0.033	19.18	24.20	18.78	24.44	22.00	0.13	0.043	Dominant
rs595958	74750694	Intron 1	C	T	0.354	19.52	19.01	19.19	19.70	17.44	0.53	0.28	Recessive
rs918836	74777539	5' UTR	C	G	0.278	19.03	19.48	18.87	18.79	19.38	0.91	0.66	Recessive

Abbreviations: AUDIT, Alcohol Use Disorder Identification Test; MAF, minor allele frequency.

^abp = base-pair position on NCBI dbSNP Build 128.

^bThe allele with the lowest frequency is italicised.

^cMinor allele frequency of the italicised allele in the volunteers from the general population (n = 201).

^dAllelic AUDIT score means were calculated in Qtphase¹⁷.

^eGenotypic AUDIT score means were calculated in SAS (SAS Institute, version 8.0, Cary, NC) using a general test of association.

^fProbability for general association between each SNP and the AUDIT score using analysis of variance models.

^gLowest probability of association assuming a genetic mode of inheritance (given in Table) with respect to allele 2.