Table 3.
Genotypic and allelic analysis of the ALDH1A1 rs348479, rs6l0529 and rs348449 polymorphisms in Finnish controls, problem drinkers and clinically treated alcoholic subjects
| SNPa and groupb | Number | Group mean AUDIT score | MAF (%) | Genotype | Genotypic | Allelic | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| p-valuec | OR (95% Cl)d | p valuec | OR (95% Cl)d | |||||||
| rs348479 | GG | GT | TT | (TT and TG) vs GG | ||||||
| controls | 105 | 6.26 | 18.1 | 6.7 | 22.9 | 70.4 | Ref | Ref | Ref | Ref |
| problem | 64 | 28.27 | 18.0 | 3.1 | 29.7 | 67.2 | 0.4 | 1.01 (0.57-1.79) | 1.0 | 1.01 (0.57-1.79) |
| alcoholic | 104 | 27.74 | 14.9 | 0 | 29.8 | 70.2 | 0.019 | N/A | 0.4 | 1.26 (0.75-2.12) |
| rs610529 | AA | AG | GG | GG vs (GA and AA) | ||||||
| controls | 105 | 6.26 | 39.5 | 37.1 | 46.7 | 16.2 | Ref | Ref | Ref | Ref |
| problem | 64 | 28.27 | 37.5 | 35.9 | 53.1 | 10.9 | 0.6 | 0.92 (0.58-1.44) | 0.7 | 0.92 (0.58-1.44) |
| alcoholic | 104 | 27.74 | 29.8 | 46.1 | 48.1 | 5.8 | 0.045 | 0.32 (0.12-0.84) | 0.040 | 0.65 (0.43-0.98) |
| rs348449 | AA | AG | GG | AA vs (AG and GG) | ||||||
| controls | 105 | 6.26 | 1.0 | 98.1 | 1.9 | 0 | Ref | Ref | Ref | Ref |
| problem | 64 | 28.27 | 7.0 | 87.5 | 10.9 | 1.6 | 0.017 | 7.36 (1.51-35.84) | 0.003 | 7.87 (1.67-37.01) |
| alcoholic | 104 | 27.74 | 3.4 | 93.3 | 6.7 | 0 | 0.09 | 3.72 (0.75-18.33) | 0.1 | 3.62 (0.74-17.64) |
aThe population (n = 305) SNP allele frequencies are as follows: rs348479 G allele frequency = 0.17, rs610529 G allele frequency = 0.37 and rs348449 G allele frequency = 0.03.
bThe three groups are: (1) Controls (AUDIT score ≤ 12); (2) Problem drinkers (AUDIT score ≥20, not treated for alcoholism); and (3) Clinically treated alcoholics.
cGenotype and allele distributions of the problem drinkers and treated alcoholic subjects were each compared with those in the control group using two-sided Pearson's chi-square or Fisher exact tests, respectively.
dOdds ratios (OR) and Wald 95% confidence intervals (95% CI) were determined separately for the allele and genotype counts of problem drinkers and treated alcoholic subjects versus control drinkers. Genotype odds ratios for each SNP were calculated as follows: rs348479 (GG versus [GT and TT]), rs6l0529 ([AA and AG] versus GG) and rs348449 (AA versus [AG and GG]).
Abbreviations: MAF, minor allele frequency; N/A, not applicable; Ref, reference group.