Table S1.
Results from simulations in which the relationship between FEV and confounders was modelled using the CAMP data with no truncation
| N | Heritability | Allele frequency | Power in population-based design (%) | Power in family-based design (%) | Avg. R2 | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FEV | PPFEV | FEV adj. | PPFEV adj. | FEV | PPFEV | FEV adj. | PPFEV adj. | FEV adj. | PPFEV adj. | |||
| 100 | 0.01 | 0.05 | 7.1 | 14.3 | 17.0 | 15.7 | 5.9 | 8.3 | 9.2 | 9.0 | 81.4 | 21.1 |
| 0.1 | 7.1 | 14.5 | 17.1 | 15.9 | 5.7 | 8.7 | 9.4 | 8.8 | 81.4 | 21.3 | ||
| 0.2 | 7.4 | 13.7 | 17.3 | 15.7 | 6.0 | 9.0 | 9.7 | 9.4 | 81.4 | 21.6 | ||
| 0.025 | 0.05 | 10.5 | 26.6 | 34.8 | 31.0 | 7.3 | 14.1 | 16.1 | 14.8 | 81.2 | 21.2 | |
| 0.1 | 10.7 | 26.9 | 34.9 | 30.7 | 7.5 | 15.1 | 17.5 | 15.8 | 81.2 | 21.4 | ||
| 0.2 | 10.5 | 27.1 | 35.1 | 31.0 | 7.7 | 15.6 | 18.6 | 16.3 | 81.2 | 22.0 | ||
| 0.05 | 0.05 | 16.7 | 45.4 | 59.7 | 53.3 | 9.7 | 23.3 | 27.5 | 24.5 | 80.8 | 21.2 | |
| 0.1 | 16.7 | 46.3 | 60.7 | 54.0 | 9.9 | 25.9 | 31.0 | 27.1 | 80.8 | 21.8 | ||
| 0.2 | 16.5 | 45.9 | 60.1 | 53.5 | 11.1 | 26.0 | 32.5 | 28.4 | 80.8 | 22.4 | ||
| 400 | 0.01 | 0.05 | 13.8 | 36.7 | 50.8 | 42.9 | 9.1 | 21.0 | 27.5 | 23.3 | 81.0 | 18.2 |
| 0.1 | 14.0 | 37.3 | 50.9 | 43.0 | 10.1 | 21.7 | 28.9 | 25.1 | 81.0 | 18.6 | ||
| 0.2 | 13.8 | 37.3 | 51.4 | 43.6 | 9.4 | 21.7 | 28.8 | 25.0 | 81.0 | 18.9 | ||
| 0.025 | 0.05 | 28.3 | 70.3 | 87.5 | 78.9 | 16.4 | 45.5 | 58.0 | 50.5 | 80.8 | 18.4 | |
| 0.1 | 28.0 | 72.3 | 88.3 | 80.0 | 16.1 | 45.5 | 59.7 | 51.9 | 80.8 | 18.7 | ||
| 0.2 | 28.1 | 72.2 | 88.5 | 80.0 | 16.3 | 45.1 | 59.6 | 51.5 | 80.8 | 19.3 | ||
| 0.05 | 0.05 | 50.6 | 92.6 | 99.2 | 96.1 | 27.3 | 70.1 | 83.6 | 76.3 | 80.4 | 18.4 | |
| 0.1 | 51.5 | 92.9 | 99.3 | 96.2 | 27.7 | 71.9 | 86.8 | 79.0 | 80.4 | 19.0 | ||
| 0.2 | 51.3 | 93.1 | 99.5 | 96.3 | 28.8 | 72.9 | 88.0 | 80.0 | 80.4 | 19.6 | ||
| 800 | 0.01 | 0.05 | 23.5 | 60.1 | 80.0 | 69.0 | 13.9 | 37.6 | 49.9 | 42.6 | 80.9 | 17.6 |
| 0.1 | 23.4 | 61.1 | 80.6 | 69.4 | 14.0 | 38.0 | 51.3 | 43.0 | 81.0 | 17.7 | ||
| 0.2 | 23.6 | 61.2 | 80.7 | 69.5 | 13.7 | 36.7 | 51.0 | 42.1 | 81.0 | 18.1 | ||
| 0.025 | 0.05 | 50.5 | 92.2 | 99.4 | 95.3 | 28.8 | 71.5 | 86.0 | 78.1 | 80.7 | 17.7 | |
| 0.1 | 50.3 | 92.3 | 99.4 | 95.3 | 28.3 | 72.0 | 87.8 | 78.8 | 80.7 | 17.9 | ||
| 0.2 | 49.8 | 92.6 | 99.5 | 95.6 | 28.3 | 71.2 | 88.8 | 79.1 | 80.7 | 18.6 | ||
| 0.05 | 0.05 | 80.3 | 97.8 | 100.0 | 98.3 | 49.9 | 91.8 | 98.9 | 95.0 | 80.3 | 17.6 | |
| 0.1 | 80.2 | 97.9 | 100.0 | 98.3 | 51.6 | 92.7 | 99.1 | 95.3 | 80.3 | 18.1 | ||
| 0.2 | 80.2 | 97.9 | 100.0 | 98.2 | 50.7 | 92.3 | 99.4 | 95.5 | 80.3 | 19.0 | ||
FEV, forced expiratory volume; PPFEV, percentage of predicted FEV