Table S2.
Results from simulations in which the relationship between FEVand confounders was determined by published FEV prediction equations with no truncation
| N | Heritability | Allele frequency | Power in population-based design (%) | Power in family-based design (%) | Avg. R2 | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FEV | PPFEV | FEV adj. | PPFEV adj. | FEV | PPFEV | FEV adj. | PPFEV adj. | FEV adj. | PPFEV adj. | |||
| 100 | 0.01 | 0.05 | 6.9 | 15.6 | 17.0 | 16.5 | 5.5 | 9.0 | 9.3 | 9.1 | 84.4 | 6.6 |
| 0.1 | 6.4 | 15.9 | 16.9 | 16.8 | 5.4 | 9.5 | 9.3 | 9.5 | 84.5 | 6.6 | ||
| 0.2 | 6.6 | 15.7 | 16.6 | 16.5 | 6.0 | 9.7 | 9.6 | 9.6 | 84.4 | 6.8 | ||
| 0.025 | 0.05 | 9.7 | 31.4 | 32.8 | 32.3 | 6.7 | 16.0 | 15.7 | 15.4 | 84.2 | 6.7 | |
| 0.1 | 9.7 | 32.2 | 34.1 | 33.4 | 7.1 | 16.9 | 17.0 | 16.7 | 84.3 | 6.7 | ||
| 0.2 | 8.9 | 31.4 | 33.7 | 32.3 | 7.5 | 18.2 | 18.2 | 17.7 | 84.2 | 6.8 | ||
| 0.05 | 0.05 | 14.6 | 56.2 | 59.3 | 57.2 | 8.7 | 27.0 | 26.8 | 26.0 | 84.0 | 6.8 | |
| 0.1 | 14.6 | 56.3 | 59.1 | 57.1 | 8.9 | 29.8 | 30.2 | 29.0 | 83.9 | 6.8 | ||
| 0.2 | 14.3 | 57.5 | 60.3 | 58.3 | 10.0 | 31.3 | 31.6 | 30.8 | 83.9 | 6.8 | ||
| 400 | 0.01 | 0.05 | 12.2 | 46.9 | 49.5 | 47.3 | 8.2 | 25.4 | 26.2 | 25.3 | 84.1 | 2.1 |
| 0.1 | 12.5 | 45.9 | 49.5 | 46.1 | 9.1 | 26.7 | 28.3 | 26.9 | 84.1 | 2.2 | ||
| 0.2 | 12.5 | 47.6 | 50.6 | 47.7 | 8.5 | 27.1 | 27.9 | 26.9 | 84.1 | 2.2 | ||
| 0.025 | 0.05 | 24.1 | 84.5 | 86.7 | 84.7 | 14.2 | 54.5 | 56.6 | 54.0 | 83.9 | 2.2 | |
| 0.1 | 23.6 | 83.7 | 86.3 | 84.1 | 13.8 | 55.9 | 58.4 | 55.8 | 83.9 | 2.2 | ||
| 0.2 | 24.1 | 84.8 | 87.4 | 85.0 | 13.9 | 55.7 | 58.1 | 55.5 | 83.9 | 2.3 | ||
| 0.05 | 0.05 | 43.3 | 98.0 | 99.1 | 98.1 | 23.2 | 80.9 | 82.6 | 80.4 | 83.6 | 2.2 | |
| 0.1 | 43.1 | 98.5 | 99.4 | 98.6 | 23.4 | 83.6 | 85.7 | 83.2 | 83.5 | 2.3 | ||
| 0.2 | 43.0 | 98.7 | 99.3 | 98.8 | 24.3 | 84.4 | 86.8 | 84.0 | 83.5 | 2.4 | ||
| 800 | 0.01 | 0.05 | 20.3 | 73.9 | 77.6 | 74.3 | 12.4 | 46.6 | 48.6 | 46.0 | 84.0 | 1.3 |
| 0.1 | 19.3 | 75.8 | 79.1 | 75.9 | 12.2 | 47.2 | 49.8 | 47.0 | 84.1 | 1.3 | ||
| 0.2 | 20.0 | 75.6 | 79.0 | 75.8 | 11.9 | 47.0 | 49.4 | 46.6 | 84.0 | 1.3 | ||
| 0.025 | 0.05 | 43.3 | 98.1 | 99.2 | 98.2 | 24.5 | 82.9 | 84.9 | 82.5 | 83.9 | 1.3 | |
| 0.1 | 42.7 | 98.2 | 99.2 | 98.2 | 23.8 | 84.5 | 86.8 | 84.4 | 83.8 | 1.3 | ||
| 0.2 | 42.2 | 98.0 | 99.3 | 98.1 | 23.6 | 84.6 | 87.2 | 84.5 | 83.8 | 1.4 | ||
| 0.05 | 0.05 | 71.0 | 99.6 | 100.0 | 99.6 | 41.9 | 97.7 | 98.7 | 97.6 | 83.5 | 1.3 | |
| 0.1 | 71.5 | 99.6 | 100.0 | 99.6 | 43.4 | 98.2 | 99.0 | 98.0 | 83.5 | 1.4 | ||
| 0.2 | 71.7 | 99.5 | 100.0 | 99.5 | 42.7 | 98.4 | 99.3 | 98.3 | 83.5 | 1.4 | ||
FEV, forced expiratory volume; PPFEV, percentage of predicted FEV.