Table S3.

Results from simulations in which the relationship between FEV and confounders was modelled using the CAMP data, and phenotype data were truncated to exclude individuals with PPFEV ≤ 80 percent

N	Heritability	Allele frequency	Power in population-based design (%)				Power in family-based design (%)				Avg. R2 (%)
			FEV	PPFEV	FEV adj.	PPFEV adj.	FEV	PPFEV	FEV adj.	PPFEV adj.	FEV adj.	PPFEV adj.
100	0.01	0.05	6.7	13.2	16.4	15.0	5.1	7.4	8.5	7.6	83.8	25.6
		0.1	6.5	12.5	15.4	14.1	5.6	7.4	8.8	8.1	83.8	25.5
		0.2	6.7	11.8	15.3	14.0	5.3	7.6	9.2	8.4	83.7	26.2
	0.025	0.05	9.4	24.2	32.8	29.1	6.3	11.6	14.6	13.2	83.5	25.5
		0.1	9.1	23.7	31.5	27.9	6.4	13.0	15.2	14.1	83.5	25.9
		0.2	8.8	22.0	29.9	26.3	6.9	12.7	15.5	14.0	83.4	26.3
	0.05	0.05	14.5	41.8	56.3	50.6	8.6	20.3	25.3	22.8	83.2	25.5
		0.1	13.7	40.4	54.6	48.3	8.2	21.5	27.2	24.0	83.1	25.9
		0.2	13.1	39.9	54.3	47.8	8.8	21.8	28.0	24.6	82.9	26.3
400	0.01	0.05	11.0	30.4	44.5	36.9	7.5	17.4	23.5	19.7	83.4	23.1
		0.1	11.2	31.0	44.1	37.1	7.7	18.1	24.0	20.8	83.4	23.3
		0.2	11.1	29.7	43.1	36.1	8.0	18.1	24.2	20.0	83.3	23.6
	0.025	0.05	21.8	63.4	83.2	73.9	13.2	38.1	51.4	44.5	83.2	23.1
		0.1	21.8	62.2	82.7	73.0	12.6	38.1	51.5	44.1	83.1	23.5
		0.2	20.6	61.9	81.6	72.0	12.9	36.2	50.7	42.9	83.0	23.8
	0.05	0.05	41.7	89.5	98.6	95.0	22.5	63.7	80.2	72.1	82.8	23.0
		0.1	39.4	88.9	98.6	94.7	21.0	63.7	80.5	72.3	82.7	23.3
		0.2	38.6	88.3	98.5	94.3	21.7	63.0	82.3	72.7	82.6	24.1
800	0.01	0.05	17.7	51.3	73.6	61.3	11.3	30.8	42.5	36.0	83.4	22.4
		0.1	16.6	50.7	72.2	60.3	11.3	30.1	43.7	35.7	83.3	22.6
		0.2	16.6	50.5	71.4	60.0	10.9	28.2	41.6	34.2	83.3	22.9
	0.025	0.05	38.3	87.4	98.4	93.3	20.7	63.5	80.8	71.2	83.1	22.5
		0.1	36.9	87.3	98.3	93.1	20.5	61.5	81.4	71.0	83.1	22.7
		0.2	36.2	86.6	98.2	92.8	20.0	61.2	81.6	70.8	82.9	23.2
	0.05	0.05	68.3	97.6	100.0	98.5	40.3	88.0	97.8	93.2	82.7	22.4
		0.1	67.0	97.7	100.0	98.6	39.0	88.6	98.6	94.0	82.6	22.8
		0.2	65.2	97.4	100.0	98.2	38.0	87.8	98.3	93.4	82.5	23.3

FEV, forced expiratory volume; PPFEV, percentage of predicted FEV