Table 3.
Genotype frequencies of CYP2E1 polymorphism in cases and controls
| CYP2E1 genotype | Cases (n = 86) |
Controls (n = 160) |
OR (95% CI); χ2a; p valueb | χ2; p value (overall) |
|---|---|---|---|---|
| RsaI | ||||
| c1/c1 (wild-type) | 46 (53.5%) | 112 (70.0%) | 1.0 (ref) | 6.81; 0.03 |
| c1/c2 | 15 (17.4%) | 20 (12.5%) | 1.8 (0.86-3.87); 0.11; 0.15 | |
| c2/c2 (variant) | 25 (29.1%) | 28 (17.5%) | 2.17 (1.14-4.11); 0.01; 0.01 | |
| c1/c2 or c2/c2 | 40 (46.5%) | 48 (30.0%) | 2.02 (1.17-3.48); 0.009; 0.01 | |
| 96-bp insertion | ||||
| i/i (non-insertion) | 55 (63.9%) | 130 (81.3%) | 1.0 (ref) | 12.1; 0.002 |
| i/I | 19 (22.1%) | 12 (7.5%) | 3.74 (1.7-8.23); 0.0006; 0.0009 | |
| I/I (insertion) | 12 (13.9%) | 18 (11.3%) | 1.57 (0.79-3.49); 0.25; 0.29 | |
| i/I or I/I | 31 (36.0%) | 30 (18.8%) | 2.44 (1.31-4.41); 0.003; 0.003 |
a Pearson value; bFisher exact value. Significant p values are shown in bold.